Crystallization is a natural change in honey
Purdue Extension
Purdue describes crystallization as the natural formation of sugar crystals in honey, rather than evidence of spoilage.
Based on: Purdue Extension

No. Crystallization alone does not mean that pure honey has spoiled. It is a natural physical change in which some of the dissolved sugars form crystals, making the honey grainier or more solid.
Purdue Extension explains that this process is normal. University of Arkansas Extension independently states that crystallized honey has not spoiled and explains that sugar composition and particles such as pollen affect how quickly crystals form. Creamed honey is deliberately crystallized to produce a spreadable texture.
Crystallization is different from microbial spoilage. Oregon State University Extension explains that added moisture can allow microorganisms to grow in honey. The presence of crystals therefore does not establish spoilage, but it also does not certify the safety of a particular jar or an infused honey product.
Crystals indicate a change in texture, not proof of spoilage. Added moisture and microbial growth are separate issues.
Purdue Extension
Purdue describes crystallization as the natural formation of sugar crystals in honey, rather than evidence of spoilage.
Based on: Purdue Extension
University of Arkansas System Division of Agriculture
The extension service explicitly states that crystallized honey has not spoiled. It describes how sugar composition and particles influence crystallization and notes that creamed honey is intentionally crystallized.
Based on: University of Arkansas System Division of Agriculture
Oregon State University Extension Service
The extension service explains that microorganisms can remain dormant in honey and begin growing if sufficient moisture is introduced. Infused honey can have different risks from plain honey.
Based on: Oregon State University Extension Service
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